8: Ageing, Frailty & Older People with HIV, References

Brañas F, Díaz-Álvarez J, Fernández-Luna J, et al. A 12-week multicomponent exercise program enhances frailty by increasing robustness, improves physical performance, and preserves muscle mass in older adults with HIV: MOVIhNG study. Front. Public Health 12:1373910. doi: 10.3389/fpubh.2024.1373910
Authors demonstrated that a 12-week multicomponent exercise program easily replicable in real life enhances frailty by increasing robustness

Brañas F, Ryan P, Troya J et al. Geriatric Medicine: the geriatrician’s role. European Geriatric Medicine. 2019;10(2):259-265. DOI: 10.1007/s41999- 018-0144-1

Guralnik JM, Simonsick EM, Ferrucci L, et al. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol. 1994 Mar;49(2):M85-94. doi: 10.1093/geronj/49.2.m85

Kooij KW, Wit FW, Schouten J et al. HIV infection is independently associated with frailty in middle-aged HIV type 1-infected individuals compared with similar but uninfected controls. AIDS. 2016 Jan;30(2):241-50 DOI:10.1097/ QAD.0000000000000910
A significantly higher prevalence of frailty among PWH compared to HIV-negative controls was demonstrated in a European cohort

Morley J, Vellas B, van Kan GA, et al. Frailty consensus: a call to action. J Am Med Dir Assoc. 2013 Jun;14(6):392-7. doi: 10.1016/j.jamda.2013.03.022

Rockwood K, Song X, MacKnight C, et al. A global clinical measure of fitness and frailty in elderly people. CMAJ. 2005 Aug 30;173(5):489-95. doi: 10.1503/cmaj.050051

Studenski S, Perera S, Patel K, et al. Gait speed and survival in older adults. JAMA. 2011 Jan 5;305(1):50-8. doi: 10.1001/jama.2010.1923

Verheij E, Kirk GD, Wit FW, et al. Frailty is associated with mortality and incident comorbidity among middle-aged HIV-positive and HIV negative participants. J Infect Dis. 2020;222:919–928 DOI: 10.1093/infdis/jiaa010
Authors demonstrated that frailty is a strong predictor of mortality and incident comorbidity with those who were prefrail being at intermediate risk for both outcomes

Verheij E, Wit FW, Verboeket SO, et al. Frequency, Risk Factors, and Mediators of Frailty Transitions During Long-Term Follow-Up Among People With HIV and HIV-Negative AGEhIV Cohort Participants. J Acquir Immune Defic Syndr. 2021 Jan 1;86(1):110-118. DOI:10.1097/QAI.0000000000002532
Distinct factors may contribute to frailty transitions, with many of those factors being potentially preventable and reversible

WHO Guidelines on Integrated Care for Older People (ICOPE) 2017 apps.who.int/iris/bitstream/handle/10665/258981/9789241550109-eng. pdf;j-sessionid=1D2957E0CEEB6271255FBA6F30084771?sequence=1
The recommendations provided in these WHO guidelines on integrated care for older people (ICOPE) offer evidence-based guidance on the appropriate approaches to detect and manage important declines in physical and mental capacities as they are strong predictors of mortality and care dependency in older age