Tests: Fibrosis / Cirrhosis

Cut-off Values of Non-invasive Tests for the Detection of Advanced Fibrosis and Cirrhosis

HIV/Hepatitis C co-infection

HIV/Hepatitis C co-infection (according to EASL recommendations on Treatment of Hepatitis C 2020)

Test	Fibrosis stage	Cut-off	Sensitivity (%)	Specificity (%)	Positive predictive value (%)	Negative predictive value (%)
Fibroscan	F3*	10 kPa	72	80	62	89
	F4*	13 kPa	72-77	85-90	42-56	95-98
APRI	F4	2	48	94	n.a.	n.a.
		1	77	75	n.a.	n.a.
Fib-4	F4	3.25	55	92	n.a.	n.a.
		1.45	90	58	n.a.	n.a.

These cut-offs were derived from different studies and the optimal values might vary between populations and must be interpreted together with the individual clinical assessment

* The distinction between F3 and F4 is often imprecise and must be interpreted in the individual clinical context

HIV/Hepatitis B co-infection

HIV/Hepatitis B co-infection

Test	Fibrosis stage	Cut-off	Sensitivity (%)	Specificity (%)	Positive predictive value (%)	Negative predictive value (%)
Fibroscan	F3	7.6 kPa	85	87	77	92
	F4	9.4 kPa	92	94	79	98
APRI	F4	2	35	89	26	92
		1	65	75	22	95