2: ARV Treatment & Prevention, References
Cohen MS, Chen YQ, McAuley M et al. Antiretroviral Therapy for the Prevention of HIV-1 Transmission. N Engl J Med 2016; 375:830-839. DOI:10.1056/ NEJMoa1600693
Insight Start study group: Lundgren JD, Babiker AG, Gordin F et al. Initiation of antiretroviral therapy in early asymptomatic HIV infection. N Engl J Med. 2015 Aug 27; 373(9):795-807 DOI:10.1056/NEJMoa1506816
Landovitz RJ, Donnell D, Clement ME, et al. HPTN 083 Study Team. Cabotegravir for HIV Prevention in Cisgender Men and Transgender Women.N Engl J Med. 2021 Aug 12;385(7):595-608. doi: 10.1056/NEJMoa2101016. PMID: 34379922
First study to demonstrate the effectiveness of cabotegravir in MSM and TGW
Lockman S, Brummel SS, Ziemba L, et al. Efficacy and safety of dolutegravir with emtricitabine and tenofovir alafenamide fumarate or tenofovir disoproxil fumarate, and efavirenz, emtricitabine, and tenofovir disoproxil fumarate HIV antiretroviral therapy regimens started in pregnancy (IMPAACT 2. Lancet. 2021;397(10281):1276-1292. doi:10.1016/S0140-6736(21)00314-7
Randomized trial including HIV-1 pregnant women at 14–28 weeks’ gestation, comparing TAF/FTC + DTF vs. TDF/FTC + DTG vs. TDF/FTC/EFV. At delivery, DTG regimens were superior to TDF/FTC/EFV in virological efficacy. TAF/FTC + DTG had the lowest frequency of composite adverse pregnancy outcomes and of neonatal deaths
Luetkemeyer AF, Donnell D, Dombrowski JC, et al. DoxyPEP Study Team. Postexposure Doxycycline to Prevent Bacterial Sexually Transmitted Infections N Engl J Med. 2023 Apr 6;388(14):1296-1306. doi: 10.1056/ NEJMoa2211934. PMID: 37018493
Study among MSM on PrEP or living with HIV showing the reduction of STI incidence with doxycycline PEP
Molina JM, Bercot B, Assoumou L, et al. ANRS 174 DOXYVAC Study Group. Doxycycline prophylaxis and meningococcal group B vaccine to prevent bacterial sexually transmitted infections in France (ANRS 174 DOXYVAC): a multicentre, open-label, randomised trial with a 2 × 2 factorial design. Lancet ID, 2024 May. doi : 10.1016/S1473-3099(24)00236-6
Doxycycline PEP strongly reduced the incidence of chlamydia and syphilis in MSM, but the 4CmenB vaccine did not show efficacy for gonorrhoea
Molina JM, Ghosn J, Assoumou L, et al. ANRS PREVENIR Study Group. Daily and on-demand HIV pre-exposure prophylaxis with emtricitabine and tenofovir disoproxil (ANRS PREVENIR): a prospective observational cohort study. Lancet HIV. 2022 Aug;9(8):e554-e562. doi: 10.1016/S2352- 3018(22)00133-3. Epub 2022 Jun 27. PMID: 35772417
Large cohort of MSM using oral TDF/FTC for PrEP either daily or on demand with a very low and similar HIV incidence
Paton NI, Musaazi J, Kityo C, et al. Efficacy and safety of dolutegravir or darunavir in combination with lamivudine plus either zidovudine or tenofovir for second-line treatment of HIV infection (NADIA): week 96 results from a prospective, multicentre, open-label, factorial, randomised, non-inferiority trial. Lancet HIV. 2022; S2352301822000923. doi:10.1016/S2352- 3018(22)00092-3
Randomized trial where switching to DTG based regimen is non inferior to DRV based regimen 96 weeks after first line treatment failure but is a greater risk of resistance. Tenofovir should be continued rather than being switched to zidovudine
Patel K, Huo Y, Jao J, et al. Pediatric HIV/AIDS Cohort Study; Swiss Mother and Child HIV Cohort Study. Dolutegravir in Pregnancy as Compared with Current HIV Regimens in the United States. N Engl J Med. 2022 Sep 1;387(9):799-809. doi: 10.1056/NEJMoa2200600. PMID: 36053505
No clear differences in adverse birth outcomes with dolutegravir-based ART as compared with non-dolutegravir-based ART, although samples were small
Segal-Maurer S, DeJesus E, Stellbrink HJ et al. CAPELLA Study Investigators. Capsid Inhibition with Lenacapavir in Multidrug-Resistant HIV-1 Infection. N Engl J Med. 2022 May 12;386(19):1793-1803. doi: 10.1056/ NEJMoa2115542. PMID: 35544387
First study to demonstrate the antiviral activity of lenacapavir in patients with multiresistant HIV-1
World Health Organization-WHO. Hiv Prevention, Infant Diagnosis, Antiretroviral Initiation and Monitoring Guidelines; 2021
Last WHO guidance including updated recommendation to initiate ART as soon as possible after initiating TB treatment when there is TB-HIV co-infection, irrespective of CD4 count (except if signs/symptoms of TB meningitis are present)
Orkin C, Molina JM, Cahn P, et al. Safety and efficacy of doravirine as first-line therapy in adults with HIV-1: week 192 results from the open-label extensions of the DRIVE-FORWARD and DRIVE-AHEAD phase 3 trials. Lancet HIV. 2024 Feb;11(2):e75-e85. doi: 10.1016/S2352-3018(23)00258-8
Randomized trial where DOR + 2NRTIs was non-inferior compared to DRV/r + NRTIs or to TDF/ FTC/EFV in HIV-1 ART-naïve participants at 192 weeks
Holt LM, Short WR, Momplaisir F, et al. Bictegravir Use During Pregnancy: A Multi-Center Retrospective Analysis Evaluating HIV Viral Suppression and Perinatal Outcomes. Clin Infect Dis. 2024 Apr 26:ciae218. doi: 10.1093/cid/ciae218
In this cohort of pregnant persons with HIV, use of BIC was associated with high levels of viral suppression and similar perinatal outcomes to published literature
Ombajo LA, Penner J, Nkuranga J et al. Second-Line Switch to Dolutegravir for Treatment of HIV Infection. N Engl J Med. 2023 Jun 22;388(25):2349-2359. doi: 10.1056/NEJMoa2210005
In patients with viral suppression with no information on the presence of drug-resistance mutations, dolutegravir treatment was noninferior to a regimen containing a ritonavir-boosted PI when the patients were switched from a PI/r-based regimen
Kityo C, Mambule I, Musaazi J et al. Switch to long-acting cabotegravir and rilpivirine in virologically suppressed adults with HIV in Africa (CARES): week 48 results from a randomised, multicentre, open-label, non-inferiority trial. Lancet Infect Dis. 2024 May 28:S1473-3099(24)00289-5
In suppressed people with HIV, including 50% of viral subtype A1, long-acting therapy had non-inferior efficacy compared with oral therapy