Varicella Zoster Virus (VZV)

Varicella zoster virus infections

Treatment

Diagnosis: typical clinical appearance with/without antibody testing, OR antigen testing / PCR / culture of swab / CSF / biopsy

During treatment: monitor renal function, adjust drug dose in renal impairment

  Drug / Dose Comments
Primary Varicella infection (Chickenpox) valaciclovir
1000 mg tid po
5-7 days
Herpes Zoster (Shingles): Not disseminated   valaciclovir
1000 mg tid po
7-10 days
OR famciclovir
500 mg tid po
7-10 days
OR aciclovir 
800 mg x 5/day po
7-10 days
Herpes Zoster: Disseminated aciclovir
10 mg/kg tid iv
10-14 days
Encephalitis (including vasculitis) aciclovir
10-15 mg/kg tid iv
14-21 days