Herpes Simplex Virus (HSV)

Herpes simplex virus infections

Treatment

Diagnosis: antigen testing / PCR / culture of swab / CSF / biopsy. Clinical appearance of skin lesions not reliable

During treatment: monitor renal function, adjust drug dose in renal impairment

  Drug / Dose Comments
Initial and recurrent genital /
mucocutaneous HSV
  See Sexual and Reproductive Health of Men and Women Living with HIV
Severe mucocutaneous lesions aciclovir 5 mg/kg tid iv After lesions begin to regress, switch to oral treatment until lesions have healed
Encephalitis aciclovir 10 mg/kg tid iv 14-21 days
Aciclovir resistant mucocutaneous HSV infection foscarnet 90 mg/kg bid iv Until clinical response