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Contents
Summary of Changes from v12.0 to v12.1
Abbreviations
Version Information
Part I: Prevention & Management of HIV & Related Infections
1: Assessment of Initial & Subsequent Visits
2: Antiretroviral Treatment & Prevention
Readiness to Start/Maintain ART
Initiation of ART: No Prior ART Exposure
Initial Regimens: ART-naïve Adults
Primary HIV Infection (PHI)
Switch Strategies
Virological Failure
Pregnancy and HIV
ART: TB/HIV Co-infection
Post-exposure Prophylaxis (PEP)
Pre-exposure Prophylaxis (PrEP)
ARV Adverse Effects & Drug Classes
3: Drug-drug Interactions & Other Prescribing Issues
DDIs, Prescribing, Overview
Drug-drug Interactions
ARVs & non-ARVs
Analgesics & ARVs
Anticoagulants/Antiplatelet Agents & ARVs
Antidepressants & ARVs
Antihypertensives & ARVs
Anti-infective Drugs for OIs and STIs and ARVs
Anti-malarial Drugs & ARVs
Anti-tuberculosis Drugs & ARVs
Anxiolytics & ARVs
Bronchodilators & ARVs
Contraceptives & ARVs
Corticosteroids & ARVs
COVID-19 Therapies & ARVs
Hormone Replacement Therapy (HRT) & ARVs
Immunosuppressants & ARVs
Pulmonary Antihypertensives & ARVs
Viral Hepatitis Drugs & ARVs
Other Prescribing Issues
ARVs: Swallowing Difficulties
ARV Dosing: Hepatic Impairment
ARV Dosing: Renal Impairment
Non-ARV Drug Dosing: Renal Insufficiency
Prescribing in Older Persons with HIV
Drug Classes To Avoid in Older Persons with HIV
Drug Classes to Deprescribe in Older Persons with HIV in Presence of Certain Conditions
Hormone Therapy: Gender Transitioning
4: Treatment & Prevention of other infections
4.1 Viral Hepatitis Co-infection
Clinical Management and Treatment of Viral Hepatitis Co-infections
Treatment and Monitoring of Persons with HBV/HIV Co-infection
HCV/HIV Co-infection
Treatment and Monitoring of Persons with HCV/HIV Co-infection
HCV Treatment Options
DDIs: Viral Hepatitis Drugs & ARVs
Tests: Fibrosis / Cirrhosis
Hepatitis D and E Infection
4.2 Opportunistic Infections & Other Co-infections
OI Overview & When to Start ART
Immune Reconstitution Inflammatory Syndrome (IRIS)
Primary Prophylaxis of OIs
Bacillary Angiomatosis
Candidiasis
COVID-19
Cryptococcosis
Cryptosporidiosis
Cystoisosporiasis
Cytomegalovirus (CMV)
Herpes Simplex Virus (HSV)
Histoplasmosis
Leishmaniasis (visceral leishmaniasis)
Mpox
Non-Tuberculous Mycobacteria (NTM)
Pneumocystis jirovecii Pneumonia (PcP)
Progressive Multifocal Leukoencephalopathy (PML)
Talaromycosis
Toxoplasma gondii Encephalitis
Tuberculosis
Varicella Zoster Virus (VZV)
4.3 Sexually Transmitted Infections
Prophylaxis for Bacterial STIs
STI Screening and Treatment
4.4 Immunisation in Persons with HIV
5: Paediatric HIV Management, Prophylaxis & Feeding
ART: Initiation and Initial Regimen
First Line Options, Formulations, Dosing
Switch Strategies, Special Situations
Adherence, Virological Failure and Second Line ART
Postnatal Prophylaxis and Infant Feeding
Part II: Prevention & Management of Co-morbidities and Other Topics
Co-morbidities Overview
1: Cancer
Cancer: Screening Methods
Cancer: Treatment Monitoring
2: Cardiovascular & Metabolic Complications
Lifestyle Interventions
Cardiovascular Disease
Prevention of Cardiovascular Disease
Hypertension: Diagnosis, Grading & Management
Hypertension: Drug Sequencing Management*
DDIs: Antihypertensives & ARVs
Type 2 Diabetes
Dyslipidemia
Dyslipidaemia
Treatment Goals for LDL-c to Reduce Cardiovascular Risk in Individuals with High and Very High Cardiovascular Disease Risk*
Lipodystrophy and Obesity
3: Bone Health
4: Kidney Complications
Kidney Disease: Definition, Diagnosis & Management
ARV-associated Nephrotoxicity
Proximal Renal Tubulopathy (PRT)
ARV dosing: renal impairment
5: Liver Complications
Increased ALT/AST: Work-up & Management
Liver Cirrhosis: Classification, Surveillance
Liver Cirrhosis: Management
Metabolic Dysfunction-Associated Steatotic Liver-Disease (MASLD)
ARV Dosing: Hepatic Impairment
6: Pulmonary Complications
Chronic Lung Disease
DDI: Bronchodilators & ARVs
DDI: Pulmonary Antihypertensives & ARVs
7: Cognition, Mental Health & Substance Use
Depression & Anxiety Disorders
Depression: Screening, Diagnosis and Management
Antidepressants: Classification, Doses, Safety, Adverse Effects
DDI: Antidepressants and ARVs
Anxiety Disorders: Screening and Diagnosis
Anxiety Disorders: Management
Anxiolytic Treatment: Classification, Doses, Adverse Effects
DDI: Anxiolytics & ARVs
Cognitive Impairment
Alcohol Use
Chemsex
Opioid Addiction: Substitution Therapy
8: Ageing, Frailty & Older People with HIV
Frailty
Falls
Managing Older Persons with HIV
9: Other Co-morbidities & Other Topics
9.1 Travel
Travel
Antimalarials & ARVs: DDI
9.2 Solid Organ Transplantation
Solid Organ Transplantation (SOT)
DDI: Immunosuppressants & ARVs
9.3 PROMs
9.4 Sexual Health
Sexual & Reproductive Health
Sexual Dysfunction
Treatment of Sexual Dysfunction
References
Prevention & Management of HIV & Related Infections, References
1: Assessment of Initial & Subsequent Visits, References
2: ARV Treatment & Prevention, References
3: DDIs & Other Prescribing Issues, References
4.1: Viral Hepatitis Co-infections, References
4.2: Opportunistic Infections and COVID-19, References
5: Paediatric HIV Treatment, References
Prevention & Management of Co-morbidities and Other Topics, References
1: Cancer, References
2: Cardiovascular & Metabolic Complications, References
3: Bone Health, References
4: Kidney Complications, References
5: Liver Complications, References
6: Pulmonary Complications, References
7: Cognition, Mental Health & Substance Use, References
8: Ageing, Frailty & Older People with HIV, References
9: Other Co-morbidities & Other Topics, References
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