Tests: Fibrosis / Cirrhosis

Cut-off Values of Non-invasive Tests for the Detection of Significant Fibrosis and Cirrhosis

HIV/Hepatitis C co-infection

HIV/Hepatitis C co-infection (according to EASL recommendations on Treatment of Hepatitis C 2018 [1])

 Test Fibrosis stage Cut-off (kPA) Sens (%)  Spec (%)  Positive predictive value (%) Negative predictive value (%)
 Fibroscan  F3*  10  72  80  62  89
   F4*  13  72-77  85-90  42-56  95-98
 APRI  F4   2  48  94  n.a.  n.a.
     1  77  75  n.a.  n.a.
 Fib-4  F4  3.25  55  92  n.a.  n.a.
     1.45  90  58  n.a.  n.a.

 

These cut-offs were derived from different studies and the optimal values might vary between populations and must be interpreted together with the individual clinical assessment
* The distinction between F3 and F4 is often imprecise and must be interpreted in the individual clinical context

HIV/Hepatitis B co-infection

HIV/Hepatitis B co-infection [2], [3], [4]

 Test  Fibrosis stage  Cut-off (kPA)  Sens (%)  Spec (%)  Positive predictive value (%) Negative predictive value (%) 
 Fibroscan  F3  7.6  85  87  77  92
   F4  9.4  92  94  79  98
 APRI  F4  2  35  89  26  92
     1  65  75  22  95